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KMID : 0811720090130020107
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Korean Journal of Physiology & Pharmacology
2009 Volume.13 No. 2 p.107 ~ p.113
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Olibanum Extract Inhibits Vascular Smooth Muscle Cell Migration and Proliferation in Response to Platelet-Derived Growth Factor
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Choi Ok-Byung
Park Joo-Hoon
Lee Ye-Jin
Lee Chang-Kwon
Won Kyung-Jong
Kim Jung-Hwan
Lee Hwan-Myung
Kim Bok-Yung
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Abstract
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Olibanum (Boswellia serrata) has been shown to have anti-inflammatory, anti-arthritic and anticancer effects. This study determined the role of a water extract of olibanum in platelet-derived growth factor (PDGF)-stimulated proliferation and migration of rat aortic smooth muscle cells (RASMCs). PDGF-BB induced the migration and proliferation of RASMCs that were inhibited by olibanum extract in a dose-dependent manner. The PDGF-BB-increased phosphorylation of p38 mitogen-activated protein kinase (MAPK); the heat shock protein (Hsp) 27 was significantly inhibited by the olibanum extract. The effects of PDGF-BB-induced extracellular signal-regulated kinase1/2 was not altered by the olibanum extract. Treatment with olibanum extract inhibited PDGF-BB-stimulated sprout out growth of aortic rings. These results suggest that the water extract of olibanum inhibits PDGF-BB-stimulated migration and proliferation in RASMCs as well as sprout out growth, which may be mediated by the inhibition of the p38 MAPK and Hsp27 pathways.
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KEYWORD
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Olibanum, Migration, Proliferation, Rat aortic smooth muscle cells, Mitogen-activated protein kinase
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